PPARG 蛋白
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北京 101111
Quick Overview for PPARG 蛋白 (ABIN7939414)
抗原
See all PPARG 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant PPARg protein
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产品特性
- PPARg (Peroxisome Proliferator Activated Receptor Gamma), also called as PPARG or NR1C3, is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, it can bind to DNA specific PPAR response elements (PPRE) and modulate the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. It's also a key regulator of adipocyte differentiation and glucose homeostasis. PPAR-gamma acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. It plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
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Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 366-475) protein (GST tag)
PPARG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 1-477) protein (GST tag)PPARG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 209-477) protein (His tag)PPARG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS
Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 1-129) protein (His-IF2DI Tag)PPARG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Peroxisome Proliferator-Activated Receptor gamma (PPARG) (AA 1-505) protein (His-IF2DI Tag)PPARG 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PPARg protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
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别名
- PPARg
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背景
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Protein Background: PPARg (Peroxisome Proliferator Activated Receptor Gamma), also called as PPARG or NR1C3, is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. PPARg is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, it can bind to DNA specific PPAR response elements (PPRE) and modulate the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. It's also a key regulator of adipocyte differentiation and glucose homeostasis. PPARg acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. It plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Short Description: Recombinant PPARg protein was expressed in baculovirus expression system as the full length protein (accession number NP_056953.2) with an N-terminal FLAG tag. The molecular weight of the protein is 58.7 kDa.
Aliases: GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgamma
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途径
- MAPK Pathway, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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