JAK1 Protein (AA 438-1154)
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Quick Overview for JAK1 Protein (AA 438-1154) (ABIN7939210)
抗原
See all JAK1 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 438-1154
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原理
- Recombinant JAK1 (438-1154) protein
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Janus Kinase 1 (JAK1) (AA 1-1153) protein (His tag)
custom-made JAK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Janus Kinase 1 (JAK1) (AA 1-1154) protein (His tag)custom-made JAK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Janus Kinase 1 (JAK1) (AA 221-320) protein (GST tag)JAK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant JAK1 (438-1154) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- JAK1 (Janus Kinase 1 (JAK1))
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别名
- JAK1
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背景
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Protein Background: JAK1 (Janus Kinase 1) is a non-receptor tyrosine kinase which is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. It plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression It is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Diseases associated with JAK1 include Autoinflammation, Immune Dysregulation, And Eosinophilia and Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Jak1 Deficiency.
Short Description: Recombinant JAK1 (438-1154) protein that includes amino acids 438-1154 of human JAK1 protein (accession number NP_001307852.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 83.6 kDa
Aliases: Janus Kinase 1
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途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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