FLT3 Protein (AA 571-993)
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Quick Overview for FLT3 Protein (AA 571-993) (ABIN7938843)
抗原
See all FLT3 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 571-993
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原理
- Recombinant FLT3 (571-993) protein
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Fms-Related tyrosine Kinase 3 (FLT3) (AA 27-541) (Active) protein (hFc Tag)
FLT3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Fms-Related tyrosine Kinase 3 (FLT3) (AA 28-541) (Active) protein (hFc Tag)FLT3 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Fms-Related tyrosine Kinase 3 (FLT3) (AA 27-543) protein (His tag,Fc Tag)FLT3 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
Fms-Related tyrosine Kinase 3 (FLT3) (AA 28-544) (Active) protein (hFc Tag)FLT3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Fms-Related tyrosine Kinase 3 (FLT3) protein (His tag)FLT3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 75 % as determined by SDS-PAGE
Fms-Related tyrosine Kinase 3 (FLT3) (AA 27-543) (Active) protein (Fc Tag)FLT3 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant FLT3 (571-993) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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别名
- FLT3
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背景
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Protein Background: FLT3 (Fms Related Receptor Tyrosine Kinase 3) is a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. FLT3 promotes phosphorylation of SHC1 and AKT1, and activates the downstream effector MTOR and promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Diseases associated with FLT3 include Leukemia, Acute Myeloid and Acute Myeloblastic Leukemia Without Maturation.
Short Description: Recombinant FLT3 (571-993) protein that includes amino acids 571-993 of human FLT3 protein (accession number NP_004110.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 49.7 kDa.
Aliases: Fms Related Receptor Tyrosine Kinase 3
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途径
- RTK signaling
抗原
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