EPH Receptor B3 Protein (EPHB3) (AA 585-998)
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Quick Overview for EPH Receptor B3 Protein (EPHB3) (AA 585-998) (ABIN7938805)
抗原
See all EPH Receptor B3 (EPHB3) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 585-998
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原理
- Recombinant EPHB3 (585-998) protein
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EPH Receptor B3 (EPHB3) (AA 34-559) (Active) protein (His tag)
EPHB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor B3 (EPHB3) (AA 30-554) (Active) protein (His tag)EPHB3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
EPH Receptor B3 (EPHB3) (AA 1-998) protein (GST tag)EPHB3 宿主: 人 宿主: 小麦胚 Recombinant WB, AA, AP, ELISA
EPH Receptor B3 (EPHB3) (Active) protein (His tag)EPHB3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 94 % as determined by SDS-PAGE Active
EPH Receptor B3 (EPHB3) protein (DYKDDDDK Tag)EPHB3 宿主: 人 宿主: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
EPH Receptor B3 (EPHB3) protein (DYKDDDDK-His Tag)EPHB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant EPHB3 (585-998) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- EPH Receptor B3 (EPHB3)
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别名
- EPHB3
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背景
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Protein Background: EPHB3(Ephrin type-B receptor 3) is a receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally, has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
Short Description: Recombinant EPHB3 (585-998) protein that includes amino acids 585-998 of human EPHB3 protein (accession number NP_004434.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.19 kDa.
Aliases: Ephrin type-B receptor 3, EPH Receptor B3, HEK2, TYRO6, ETK2, Tyrosine-Protein Kinase TYRO6, EK2, Tyro6, EphB3, Hek2
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途径
- RTK signaling
抗原
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