EPH Receptor B1 Protein (EPHB1) (AA 565-984)
Our Local Distributor
北京 101111
Quick Overview for EPH Receptor B1 Protein (EPHB1) (AA 565-984) (ABIN7938802)
抗原
See all EPH Receptor B1 (EPHB1) 蛋白蛋白类型
宿主
资源
应用范围
-
-
产品特性
- AA 565-984
-
原理
- Recombinant EPHB1 (565-984) protein
-
-
EPH Receptor B1 (EPHB1) protein (Fc Tag)
EPHB1 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
EPH Receptor B1 (EPHB1) (Active) protein (GST tag,His tag)EPHB1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by SDS-PAGE Active
EPH Receptor B1 (EPHB1) (AA 565-984) (Active) protein (GST tag,His tag)EPHB1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
EPH Receptor B1 (EPHB1) (Active) protein (His tag)EPHB1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Recombinant EPHB1 (565-984) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.
-
注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
-
储存条件
- -80 °C
-
储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
-
-
- EPH Receptor B1 (EPHB1)
-
别名
- EPHB1
-
背景
-
Protein Background: EPHB1(Ephrin type-B receptor 1) is a receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their selfrenewal and reducing their activation and differentiation (By similarity).
Short Description: Recombinant EPHB1 (565-984) protein that includes amino acids 565-984 of human EPHB1 protein (accession number NP_004432.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.78 kDa.
Aliases: Ephrin type-B receptor 1, EPHT2, HEK6, ELK, NET, EK6, Eph Tyrosine Kinase
-
途径
- RTK signaling
抗原
-
