CAMK2D 蛋白
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北京 101111
Quick Overview for CAMK2D 蛋白 (ABIN7938672)
抗原
See all CAMK2D 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant CAMK2D protein
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Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) protein (GST tag)
CAMK2D 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 1-478) protein (GST tag)CAMK2D 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 2-115) protein (His-IF2DI Tag)CAMK2D 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) protein (DYKDDDDK Tag)CAMK2D 宿主: 小鼠 宿主: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (Transcript Variant 4) protein (Myc-DYKDDDDK Tag)CAMK2D 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)CAMK2D 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CAMK2D 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant CAMK2D protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))
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别名
- CAMK2D
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背景
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Protein Background: CAMK2D (Calcium/calmodulin-dependent protein kinase type II subunit delta) is a Calcium/calmodulindependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program.
Short Description: Recombinant CAMK2D protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001212.2) with an N-terminal FLAG tag. The molecular weight of the protein is 57.52 kDa.
Aliases: Calcium dependent protein kinase type II subunit delta, CAMKD, CaM Kinase II Delta Subunit
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途径
- WNT signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
抗原
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