ACE2 Protein (AA 18-740)
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Quick Overview for ACE2 Protein (AA 18-740) (ABIN7938599)
抗原
See all ACE2 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 18-740
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原理
- Recombinant ACE2 (18-740) protein
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Angiotensin I Converting Enzyme 2 (ACE2) protein (His tag,AVI tag,Biotin)
ACE2 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. SDS, Func
Angiotensin I Converting Enzyme 2 (ACE2) protein (His tag)ACE2 宿主: Paguma larvata 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. SDS
Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-740) (Active) protein (Biotin,His-Avi Tag)ACE2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-739) (Active) protein (His-Avi Tag)ACE2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-740) (Active) protein (hFc-Avi Tag,Biotin)ACE2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-740) (Active) protein (His-Avi Tag)ACE2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Angiotensin I Converting Enzyme 2 (ACE2) (Active) protein (His tag)ACE2 宿主: 猕猴 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
Angiotensin I Converting Enzyme 2 (ACE2) (Active) protein (Fc Tag)ACE2 宿主: 猕猴 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-740) (Active) protein (Fc Tag)ACE2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % by SDS-PAGE. SDS, Func Active
Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-740) protein (His tag)ACE2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant ACE2 (18-740) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))
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别名
- ACE2
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背景
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Protein Background: ACE2 (Angiotensin I Converting Enzyme 2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases, it is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. This protein catalyzes the cleavage of angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to the vasodilator angiotensin 1-7, which acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. ACE2 removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1] apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity.
Short Description: Recombinant ACE2 (18-740) protein that includes amino acids 18-740 of human ACE2 protein (accession number NP_001358344.1) was expressed in a baculovirus expression system, and contains a C-terminal FLAG tag. The molecular weight of the protein is 85.4 kDa.
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途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
抗原
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