BAI1 Protein (AA 31-926)
This Recombinant BAI1 protein is expressed in HEK-293 Cells.
产品编号 ABIN7829723
发货至:
中国
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Quick Overview for BAI1 Protein (AA 31-926) (ABIN7829723)
抗原
See all BAI1 蛋白
BAI1
(Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
蛋白类型
Recombinant
宿主
人
资源
HEK-293 Cells
应用范围
Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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产品特性
- AA 31-926
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原理
- Recombinant human BAI1(31-926) Protein with C-terminal Flag and Strep Tag
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特异性
- BAI1(Ala31-Leu926) Flag and Strep Tag
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产品特性
- Extracellular Domain Protein
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应用备注
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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说明
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please see Certificate of Analysis for specific instructions of reconstitution.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
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别名
- BAI1
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背景
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ADGRB1, GDAIF
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008] -
分子量
- predicted molecular mass of 102.5 kDa after removal of the signal peptide.
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UniProt
- O14514
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途径
- p53 Pathway
抗原
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