14-3-3 sigma/SFN Protein (GST tag)
Quick Overview for 14-3-3 sigma/SFN Protein (GST tag) (ABIN7669789)
抗原
See all 14-3-3 sigma/SFN (SFN) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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标记
- This 14-3-3 sigma/SFN protein is labelled with GST tag.
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原理
- Recombinant Human 14-3-3 sigma/YWHAS Protein (GST Tag)
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序列
- Met 1-Ser 248
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纯化方法
- > 94 % as determined by reducing SDS-PAGE.
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过滤
- 0.2 μm filtered
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Stratifin (SFN) (AA 1-248) protein (His tag)
custom-made SFN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Stratifin (SFN) (AA 1-248) protein (His tag)custom-made SFN 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Stratifin (SFN) (AA 1-248) protein (GST tag)SFN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 10 mM GSH, 25 % glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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别名
- 14-3-3 sigma
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背景
- 14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.,14-3-3 Protein Sigma,Epithelial Cell Marker Protein 1,HME1,SFN,Stratifin
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分子量
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calculated_mw: 50.1 kDa
observed_mw: 48 kDa
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UniProt
- P31947
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途径
- p53 Pathway, Myometrial Relaxation and Contraction
抗原
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