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Tetanus Toxin Protein (TetX)

This Native Tetanus Toxin protein is expressed in Clostridium tetani.
产品编号 ABIN7582361
发货至: 中国

Quick Overview for Tetanus Toxin Protein (TetX) (ABIN7582361)

抗原

Tetanus Toxin (TetX)

蛋白类型

Native

宿主

Clostridium tetani

资源

Clostridium tetani

应用范围

Blocking Peptide (BP)

纯度

≥97 % (HPLC)
  • 原理

    An Inhibitor of Neurotransmitter Release

    特异性


    Disulfide bonds between Cys439-Cys467 and Cys1077-Cys1093

    产品特性

    An Inhibitor of Neurotransmitter Release
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  • 应用备注

    Antigen Preadsorption Control: 1 - 100 nM

    说明

    Electrophysiology

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. Soluble in any conventional buffer containing 0.01 KH2PO4, 0.1 % gelatin and/or 0.1 % bovine serum albumin (BSA). The use of gelatin or 0.01 % BSA coated/treated glassware is recommended. Centrifuge all product preparations before use (10000 x g 5 min).

    缓冲液

    Lyophilized Powder.

    储存条件

    4 °C,-20 °C

    储存方法

    The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
  • 抗原

    Tetanus Toxin (TetX)

    别名

    Tetanus Toxin

    物质类

    Bacteria

    背景

    Tentoxylysin,Tetanus toxin is a 150 kD protein produced by the gram positive bacteria Clostridium tetani under anaerobic condition1. Tetanus toxin is a hetrodimer of A-chain (50 kD) and B-chain (100 kD) linked by one disulfide bond2,3. The A-chain has a zinc endopeptidase activity while the B-chain has a role in toxin anchoring to neuronal membranes4.Tetanus toxin spreads in the body through the lymphatic and vascular systems to the neuromuscular junction, internalized to peripheral neuron synapses, and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons to the CNS5. There, it inhibits neurotransmitter release by the specific degradation of the vesicle-secretory protein-Synaptobrevin6.

    分子量

    150 kDa

    UniProt

    P04958
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