FNDC4 Protein (AA 41-163, AA 45-167) (Fc Tag)
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- 抗原 See all FNDC4 蛋白
- FNDC4 (Fibronectin Type III Domain Containing 4 (FNDC4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 41-163, AA 45-167
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宿主
- 人, 犬, 猴, 小鼠, 大鼠
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资源
- HEK-293 Cells
- 标记
- This FNDC4 protein is labelled with Fc Tag.
- 原理
- Fc (human):FNDC4 (rec.)
- 交叉反应
- 犬, 人, 猴, 小鼠, 大鼠
- 产品特性
- FNDC4 (extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is fused at the N-terminus to the Fc portion of human IgG1. FNDC4 extracellular domain has 100 % identity between human, mouse, rat, dog and monkey.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test).
- Top Product
- Discover our top product FNDC4 蛋白
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Fibronectin Type III Domain Containing 4 (FNDC4) (AA 45-148) protein (His-IF2DI Tag)
FNDC4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Fibronectin Type III Domain Containing 4 (FNDC4) (AA 45-154) protein (GST tag)FNDC4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Fibronectin Type III Domain Containing 4 (FNDC4) (AA 1-234) protein (GST tag)FNDC4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Fibronectin Type III Domain Containing 4 (FNDC4) protein (Myc-DYKDDDDK Tag)FNDC4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 1 mg/mL after reconstitution
- 浓度
- 1 mg/mL
- 缓冲液
- Contains PBS.
- 注意事项
- After reconstitution, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1 % BSA should be used for further dilutions.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- FNDC4 (Fibronectin Type III Domain Containing 4 (FNDC4))
- 别名
- FNDC4 (FNDC4 产品)
- 背景
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Fibronectin Type III Domain-containing Protein 4, Fibronectin Type III Repeat-containing Protein 1, Fc Soluble FNDC4, FcsFNDC4
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50 % identity and 86 % similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases. Recently, a new role of FNDC4 as a hepatokine has been published. Liver primarily controls the circulating levels of FNDC4 showing tight correlation with insulin sensitivity. In addition, a new orphan adhesion G protein-coupled receptor 116 (GPR116) has been identified as a receptor of FNDC4 in white adipose tissue (WAT), thereby establishing an endocrine FNDC4-GPR116 axis in the control of systemic glucose homeostasis. Moreover, the FNDC4-GPR116 axis is impaired in diabetic patients and therapeutic injections of recombinant Fc-FNDC4 into pre-diabetic mice corrected pre-diabetic hyperglycemia.
- 分子量
- ~55-60kDa
- UniProt
- Q9H6D8
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