CD38 Protein (Fc Tag)
Quick Overview for CD38 Protein (Fc Tag) (ABIN7566110)
抗原
See all CD38 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CD38 protein is labelled with Fc Tag.
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原理
- CD38 (human):Fc (human) (rec.)
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交叉反应
- 人
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产品特性
- The extracellular domain of human CD38 (aa 43 - 300) is fused to the N-terminus of the Fc region of human IgG1.
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过滤
- Sterile filtered
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内毒素水平
- <5EU/mg protein (LAL test, Lonza).
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
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注意事项
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- CD38
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背景
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ADP-ribosyl Cyclase 1, Cyclic ADP-ribose Hydrolase 1, ADPRC 1, T10
CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.
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分子量
- ~70kDa (SDS-PAGE)
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UniProt
- P28907
抗原
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