CD276 Protein (CD276) (AA 29-245)
Quick Overview for CD276 Protein (CD276) (AA 29-245) (ABIN7566091)
抗原
See all CD276 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
产品特性
- AA 29-245
-
原理
- CD276 [B7-H3] (human) (rec.)
-
交叉反应
- 人
-
产品特性
- The extracellular domain of human CD276 [B7-H3] (aa 29-245) is untagged.
-
过滤
- Sterile filtered
-
内毒素水平
- <1EU/mg protein (LAL test, Lonza).
-
Biological Activity Comment
- Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
-
-
CD276 (CD276) (AA 29-245) protein (His tag)
CD276 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
CD276 (CD276) (AA 27-461) protein (Fc Tag)CD276 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD276 (CD276) (AA 29-245) protein (His-Avi Tag,Biotin)CD276 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD276 (CD276) (AA 29-245) protein (mFc-His Tag)CD276 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD276 (CD276) (AA 29-248) protein (His tag)CD276 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD276 (CD276) (AA 29-244) protein (Fc Tag)CD276 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD276 (CD276) (AA 28-140) protein (His-DYKDDDDK-Strep II Tag)CD276 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD276 (CD276) (AA 237-461) protein (His-DYKDDDDK-Strep II Tag)CD276 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD276 (CD276) (AA 28-238) protein (His-DYKDDDDK-Strep II Tag)CD276 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
CD276 (CD276) (AA 29-245) protein (Fc Tag,AVI tag,Biotin)CD276 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
-
注意事项
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1 % BSA should be used for further dilutions.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
-
-
- CD276
-
别名
- CD276 [B7-H3]
-
背景
-
B7-H3
CD276 (B7-H3) is a member of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T(H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. Recently, B7-H3 expression has also been found in a variety of different human cancers, including prostate cancer, clear cell renal cell carcinoma (ccRCC), non-small-cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, ovarian cancer, colorectal cancer (CRC) and urothelial cell carcinoma. B7-H3 was expressed in some human cancers and correlated with poor outcome of cancer patients.
-
分子量
- ~35-50kDa (SDS-PAGE)
-
NCBI登录号
- NP_079516
-
途径
- Cancer Immune Checkpoints
抗原
-
