BTNL2 Protein (AA 26-457) (Fc Tag)
-
- 抗原 See all BTNL2 蛋白
- BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 26-457
-
宿主
- 小鼠
-
资源
- CHO Cells
- 标记
- This BTNL2 protein is labelled with Fc Tag.
- 原理
- BTNL2 (mouse):Fc (mouse) (rec.)
- 交叉反应
- 小鼠
- 产品特性
- The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a.
- 纯度
- >98 % (SDS-PAGE)
- 过滤
- Sterile filtered
- 内毒素水平
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- A butyrophilin-like molecule that functions to inhibit T cell activation.
- Top Product
- Discover our top product BTNL2 蛋白
-
Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) (AA 1-454) protein (His tag)
custom-made BTNL2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
-
- 抗原
- BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))
- 别名
- BTNL2 (BTNL2 产品)
- 背景
-
Butyrophilin-like Protein 2
Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
- NCBI登录号
- NP_524574
-
