C-Type Lectin Domain Family 6, Member A (CLEC6A) (AA 1-209) protein (His tag)
This Recombinant protein is expressed in HEK-293 Cells.
Quick Overview for C-Type Lectin Domain Family 6, Member A (CLEC6A) (AA 1-209) protein (His tag) (ABIN7561634)
抗原
See all C-Type Lectin Domain Family 6, Member A (CLEC6A) 蛋白
C-Type Lectin Domain Family 6, Member A (CLEC6A)
蛋白类型
Recombinant
宿主
小鼠
资源
HEK-293 Cells
纯度
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
质量等级
custom-made
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产品特性
- AA 1-209
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标记
- His tag
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原理
- Predefined custom protein recombinant Clec6a Protein expressed in mammalian cells.
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序列
- MVQERQSQGK GVCWTLRLWS AAVISMLLLS TCFIASCVVT YQFIMDQPSR RLYELHTYHS SLTCFSEGTM VSEKMWGCCP NHWKSFGSSC YLISTKENFW STSEQNCVQM GAHLVVINTE AEQNFITQQL NESLSYFLGL SDPQGNGKWQ WIDDTPFSQN VRFWHPHEPN LPEERCVSIV YWNPSKWGWN DVFCDSKHNS ICEMKKIYL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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想要此Protein的其他选项吗？
!探索我们的目录蛋白和定制蛋白服务选项！Product表达系统ConjugateOriginPrice表达系统 HEK-293 CellsConjugate His tagOrigin MousePrice 8,754.22 ¥表达系统 Escherichia coli (E. coli)Conjugate His tagOrigin MousePrice 5,593.03 ¥表达系统 HEK-293 CellsConjugate Fc TagOrigin MousePrice 11,962.16 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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C-Type Lectin Domain Family 6, Member A (CLEC6A) (AA 1-209) protein (His tag)
custom-made CLEC6A 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
C-Type Lectin Domain Family 6, Member A (CLEC6A) (Active) protein (His tag)CLEC6A 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- C-Type Lectin Domain Family 6, Member A (CLEC6A)
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别名
- Clec6a
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背景
- C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2),FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:17050534, PubMed:19703985, PubMed:20493731). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:17050534, PubMed:19703985, PubMed:20493731, PubMed:32358020). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed:19124755). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed:21059925). {ECO:0000269|PubMed:17050534, ECO:0000269|PubMed:19124755, ECO:0000269|PubMed:19703985, ECO:0000269|PubMed:20493731, ECO:0000269|PubMed:21059925, ECO:0000269|PubMed:32358020}.
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分子量
- 24.3 kDa
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UniProt
- Q9JKF4
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AlphaFold
- Q9JKF4
抗原
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