GPR39 Protein (AA 1-456) (His tag)
custom-made
GPR39
宿主: 小鼠
宿主: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- 抗原 See all GPR39 蛋白
- GPR39 (G Protein-Coupled Receptor 39 (GPR39))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-456
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This GPR39 protein is labelled with His tag.
- 原理
- Made-to-order recombinant Gpr39 Protein expressed in mammalian cells.
- 序列
- MASSSGSNHI CSRVIDHSHV PEFEVATWIK ITLILVYLII FVVGILGNSV TIRVTQVLQK KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TPSYALSCKL HTFLFETCSY ATLLHVLTLS FERYIAICHP FKYKAVSGPR QVKLLIGFVW VTSALVALPL LFAMGIEYPL VNVPTHKGLN CNLSRTRHHD EPGNSNMSIC TNLSNRWEVF QSSIFGAFAV YLVVLASVAF MCWNMMKVLM KSKQGTLAGT GPQLQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ IRRIMAAAKP KHDWTRTYFR AYMILLPFSD TFFYLSSVVN PLLYNVSSQQ FRKVFWQVLC CRLTLQHANQ EKRQRARFIS TKDSTSSARS PLIFLASRRS NSSSRRTNKV FLSTFQTEAK PGEAKPQPLS PESPQTGSET KPAGSTTENS LQEQEV Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.
- 特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
- 产品特性
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Key Benefits:
- Made to order protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified. - 纯度
- > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
- 质量等级
- custom-made
- Top Product
- Discover our top product GPR39 蛋白
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G Protein-Coupled Receptor 39 (GPR39) (AA 1-453) protein (His tag)
custom-made GPR39 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
G Protein-Coupled Receptor 39 (GPR39) (AA 1-453) protein (GST tag)GPR39 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- The buffer composition is at the discretion of the manufacturer.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C.
- 有效期
- 12 months
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- 抗原
- GPR39 (G Protein-Coupled Receptor 39 (GPR39))
- 别名
- Gpr39 (GPR39 产品)
- 背景
- G-protein coupled receptor 39,FUNCTION: Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:17030183, PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (By similarity). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (PubMed:31346193). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (PubMed:21784784). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner. Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (By similarity). {ECO:0000250|UniProtKB:O43194, ECO:0000269|PubMed:17030183, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:21784784, ECO:0000269|PubMed:31346193}.
- 分子量
- 51.6 kDa
- UniProt
- Q5U431
- AlphaFold
- Q5U431
- 途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Feeding Behaviour
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