Geminin Protein (AA 1-209) (His tag)
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北京 101111
Quick Overview for Geminin Protein (AA 1-209) (His tag) (ABIN7547939)
抗原
See all Geminin (GMNN) 蛋白蛋白类型
宿主
资源
纯度
质量等级
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产品特性
- AA 1-209
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标记
- This Geminin protein is labelled with His tag.
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原理
- Predefined custom protein recombinant GMNN Protein expressed in mammalian cells.
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序列
- MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS SSTDAKPCI Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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特异性
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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产品特性
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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想要此Protein的其他选项吗？
!探索我们的目录蛋白和定制蛋白服务选项！Product表达系统ConjugateOriginPrice表达系统 Wheat germConjugate GST tagOrigin HumanPrice 5,782.24 ¥表达系统 Escherichia coli (E. coli)Conjugate His tagOrigin HumanPrice 4,094.35 ¥表达系统 Escherichia coli (E. coli)Conjugate GST tagOrigin HumanPrice 5,126.92 ¥表达系统 Escherichia coli (E. coli)Conjugate His tag,GST tagOrigin HumanPrice 6,086.73 ¥表达系统 Escherichia coli (E. coli)ConjugateOrigin HumanPrice 23,773.70 ¥表达系统 HEK-293 CellsConjugate Myc-DYKDDDDK TagOrigin HumanPrice 9,118.14 ¥表达系统 BacteriaConjugate GST tagOrigin HumanPrice 3,968.25 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Geminin, DNA Replication Inhibitor (GMNN) (AA 1-206) protein (His tag)
custom-made GMNN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Geminin, DNA Replication Inhibitor (GMNN) (AA 1-209) protein (GST tag)GMNN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Geminin, DNA Replication Inhibitor (GMNN) protein (Myc-DYKDDDDK Tag)GMNN 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The buffer composition is at the discretion of the manufacturer.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -80 °C
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储存方法
- Store at -80°C.
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有效期
- 12 months
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- Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
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别名
- GMNN
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背景
- Geminin,FUNCTION: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}.
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分子量
- 23.6 kDa
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UniProt
- O75496
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AlphaFold
- O75496
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途径
- EGFR Signaling Pathway, DNA Replication
抗原
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