DLK1 Protein (Soluble) (His tag)
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- 抗原 See all DLK1 蛋白
- DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))
- 蛋白类型
- Recombinant
- 产品特性
- Soluble
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This DLK1 protein is labelled with His tag.
- 原理
- DLK-1/Pref-1, soluble
- 序列
- AECFPACNPQ NGFCEDDNVC RCQPGWQGPL CDQCVTSPGC LHGLCGEPGQ CICTDGWDGE LCDRDVRACS SAPCANNGTC VSLDDGLYEC SCAPGYSGKD CQKKDGPCVI NGSPCQHGGT CVDDEGRASH ASCLCPPGFS GNFCEIVANS CTPNPCENDG VCTDIGGDFR CRCPAGFIDK TCSRPVTNCA SSPCQNGGTC LQHTQVSYEC LCKPEFTGLT CVKKRALSPQ QVTRLPSGYG LAYRLTPGVH ELPVQQPEHR ILKVSMKELN KKTPLEHHHH HH
- 产品特性
- Length (aa):282
- 纯度
- > 98 % by SDS-PAGE
- Top Product
- Discover our top product DLK1 蛋白
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delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-303) protein (His tag)
DLK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-305) protein (His tag)DLK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-303) protein (Fc Tag)DLK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-306) protein (His tag)DLK1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-303) protein (His tag)DLK1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % by SDS - PAGE SDS
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 25-383) protein (GST tag)DLK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- water,Centrifuge vial prior to opening. Human sDLK1/Pref1 should be reconstituted in water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.
- 缓冲液
- PBS
- 储存条件
- RT,0 °C,-20 °C
- 储存方法
- The lyophilized human sDLK1/Pref1, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted human sDLK1/Pref1 should be stored in working aliquots at -20°C.
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- 抗原
- DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))
- 别名
- DLK-1/Pref-1 (DLK1 产品)
- 背景
- Protein delta homolog 1, pG2, Fetal antigen 1, FA1, ZOG,Delta-like 1 (DLK1), also known as Pref-1 and FA1, is a transmembrane protein pertaining to the epidermal growth factor superfamily. DLK1 affects several differentiation processes, including adipogenesis, muscular and neuronal differentiation, bone differentiation, and haematopoiesis. Several reports support that DLK1 may operate as a non-canonical ligand of the NOTCH pathway. Since the NOTCH signaling pathway is essential for vascular development and physiology by controlling angiogenesis in pre- and post-natal life, it was reasoned that DLK1 could contribute to regulate this process in adult endothelial cells through the interaction with NOTCH receptors. It was found that overexpression of DLK1 inhibits migration and angiotube formation in mammalian vascular endothelial cells and disrupts normal embryonic vascularization in zebrafish. Genetic ablation of DLK1 in mice is associated with increased angiogenesis in vitro and with focal areas of retinal hyper-vascularization. Specific knockdown of the orthologous Dlk1 of zebrafish results in ectopic angiogenesis. Moreover, in a tumor angiogenesis model in zebrafish, suppression of Dlk1 promotes vessel migration towards the tumor cell mass. It was also found that the NOTCH signaling pathway is targeted by DLK1 in the context of angiogenesis and that DLK1 antagonizes NOTCH-dependent signaling in endothelial cells, while, in contrast, this signaling is enhanced in Dlk1-null mice. Collectively, these results revealed a previously unknown role for DLK1 in the vasculature as a regulator of NOTCH-mediated angiogenesis.
- 分子量
- 30.2 kDa
- 基因ID
- 8788
- NCBI登录号
- NM_003836, NP_003827
- UniProt
- P80370
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