CRHR1 蛋白
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北京 101111
Quick Overview for CRHR1 蛋白 (ABIN7538208)
抗原
See all CRHR1 蛋白蛋白类型
宿主
资源
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原理
- Human CRHR1 full length protein-synthetic nanodisc
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产品特性
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
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Corticotropin Releasing Hormone Receptor 1 (CRHR1) (AA 1-415) protein (GST tag)
CRHR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Corticotropin Releasing Hormone Receptor 1 (CRHR1) (AA 24-121) protein (GST tag)CRHR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Corticotropin Releasing Hormone Receptor 1 (CRHR1) (AA 23-121) protein (His tag)CRHR1 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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说明
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))
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别名
- CRHR1
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背景
- This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]
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分子量
- The human full length CRHR1 protein has a MW of 36.6kDa
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UniProt
- B3TIK8
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途径
- Hormone Transport, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Feeding Behaviour, Negative Regulation of Transporter Activity
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