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IL-25 Protein (His tag)

This Recombinant IL-25 protein is expressed in HEK-293 Cells.
产品编号 ABIN7520197
发货至: 中国
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Quick Overview for IL-25 Protein (His tag) (ABIN7520197)

抗原

See all IL-25 (IL25) 蛋白
IL-25 (IL25) (Interleukin 25 (IL25))

蛋白类型

Recombinant

宿主

  • 18
  • 8
  • 3
小鼠

资源

  • 18
  • 5
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

纯度

> 92 % by SDS-PAGE.
  • 标记

    This IL-25 protein is labelled with His tag.

    原理

    Recombinant Mouse IL-17E Protein

    序列

    VSLRIQEGCS HLPSCCPSKE QEPPEEWLKW SSASVSPPEP LSHTHHAESC RASKDGPLNS RAISPWSYEL DRDLNRVPQD LYHARCLCPH CVSLQTGSHM DPLGNSVPLY HNQTVFYRRP CHGEEGTHRR YCLERRLYRV SLACVCVRPR VMA

    特异性

    Val 17-Ala 169

    过滤

    0.22 μm filtered

    内毒素水平

    <0.01EU/μg
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

    浓度

    1.05 mg/mL

    缓冲液

    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

    储存条件

    -20 °C,-80 °C

    储存方法

    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • 抗原

    IL-25 (IL25) (Interleukin 25 (IL25))

    别名

    IL-17E

    背景

    Description: Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17-producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)-activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.

    Name: IL-25, Il17e, IL-17e

    基因ID

    140806

    UniProt

    Q8VHH8
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