Our Local Distributor
北京 101111
Quick Overview for IL-25 Protein (Fc Tag) (ABIN7321197)
抗原
See all IL-25 (IL25) 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
标记
- This IL-25 protein is labelled with Fc Tag.
-
原理
- Recombinant Rat Interleukin-25/IL-25 Protein (Fc Tag)(Active)
-
序列
- Val17-Ala169
-
产品特性
- A DNA sequence encoding the rat IL25 (D3ZLB1) (Val17-Ala169) was expressed, fused with Fc region of human IgG1 at the N-terminus.
-
内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
-
Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized mouse IL17BR-His at 10 μg/mL (100 μl/well) can bind rat Fc-IL25. The EC50 of rat Fc-IL25 is 0.12-0.27 μg/mL.
-
-
Interleukin 25 (IL25) (AA 33-177) (Active) protein (Biotin,His-Avi Tag)
IL25 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 25 (IL25) (Active) proteinIL25 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 25 (IL25) (AA 1-177) protein (GST tag)IL25 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 25 (IL25) (AA 17-169) protein (His tag)IL25 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 25 (IL25) (AA 33-177) protein (His tag)IL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 25 (IL25) (AA 33-177) protein (Fc Tag)IL25 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 25 (IL25) proteinIL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 25 (IL25) proteinIL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 25 (IL25) proteinIL25 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Please refer to the printed manual for detailed information.
-
缓冲液
- Lyophilized from sterile PBS, pH 7.4
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
-
- IL-25 (IL25) (Interleukin 25 (IL25))
-
别名
- Interleukin-25/IL-25
-
背景
-
Background: Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.
Synonym: IL25
-
分子量
- 46.1 kDa
-
UniProt
- D3ZLB1
抗原
-
