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IL-21 Protein (His tag)

This Recombinant IL-21 protein is expressed in HEK-293 Cells.
产品编号 ABIN7536334
发货至: 中国

Quick Overview for IL-21 Protein (His tag) (ABIN7536334)

抗原

See all IL-21 (IL21) 蛋白
IL-21 (IL21) (Interleukin 21 (IL21))

蛋白类型

Recombinant

宿主

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大鼠

资源

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HEK-293 Cells
  • 标记

    This IL-21 protein is labelled with His tag.

    原理

    Recombinant Rat IL-21 Protein

    序列

    HKSSPQRPDH LLIRLRHLMD IVEQLKIYEN DLDPELLTAP QDVKGQCEHE AFACFQKAKL KPSNTGNNKT FINDLLAQLR RRLPAKRTGN KQRHMAKCPS CDLYEKKTPK EFLERLKWLL QKMIHQHLS

    特异性

    His18-Ser146

    过滤

    0.22 μm filtered

    内毒素水平

    < 0.1EU/μg
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

    浓度

    0.77 mg/mL

    缓冲液

    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

    储存条件

    -20 °C,-80 °C

    储存方法

    Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • 抗原

    IL-21 (IL21) (Interleukin 21 (IL21))

    别名

    IL-21

    背景

    Description: IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).

    Name: Za11, IL-21, CVID11

    基因ID

    365769

    UniProt

    A3QPB9

    途径

    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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