IgG1 Fc (AA 99-330) protein (Fc Tag)
-
- 抗原
- IgG1 Fc
- 蛋白类型
- Recombinant
- 产品特性
- AA 99-330
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- Fc Tag
- 序列
- Glu99-Lys330
- 产品特性
- A DNA sequence encoding theHuman IgG1 Fc protein (P01857) (Glu99-Lys330) was expressed with a C-His.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
-
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
-
- 抗原
- IgG1 Fc
- 背景
-
Abbreviation: IgG1 Fc
Target Synonym: Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE
Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens.The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.
- 分子量
-
Calculated MW: 40 kDa
Observed MW: 35 kDa
- UniProt
- P01857
-