Caspase 3 Protein (CASP3) (AA 29-175) (His tag)
Quick Overview for Caspase 3 Protein (CASP3) (AA 29-175) (His tag) (ABIN7505516)
抗原
See all Caspase 3 (CASP3) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 29-175
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标记
- This Caspase 3 protein is labelled with His tag.
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序列
- Ser 29-Asp 175
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产品特性
- A DNA sequence encoding the Rat CASP3 protein (P55213) (Ser 29-Asp 175) was expressed with a N-His tag.
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Caspase 3 (CASP3) (AA 29-277) protein (His-IF2DI Tag)
CASP3 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Caspase 3 (CASP3) (AA 1-277) protein (GST tag)CASP3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Caspase 3 (CASP3) (AA 176-277) proteinCASP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80% by SDS-PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Caspase 3 (CASP3)
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别名
- CASP3
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背景
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Abbreviation: CASP3
Target Synonym: CASP-3,CASP3,CASP3,Casp3a,Caspase 3,Caspase 3,Casp3,Cpp32
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage .Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes .Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME).Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface.
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分子量
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Calculated MW: 16.06 kDa
Observed MW: 20 kDa
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UniProt
- P55213
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
抗原
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