Cyclin D2 Protein (CCND2) (AA 1-289) (His tag)
-
- 抗原 See all Cyclin D2 (CCND2) 蛋白
- Cyclin D2 (CCND2)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-289
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This Cyclin D2 protein is labelled with His tag.
- 序列
- Met 1-Leu289
- 产品特性
- A DNA sequence encoding the Human CCND2 protein (P30279) (Met 1-Leu289) was expressed with aN-His&C-His tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCND2 蛋白
-
Cyclin D2 (CCND2) (AA 1-289) protein (His tag)
custom-made CCND2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin D2 (CCND2) (AA 1-289) protein (His tag)custom-made CCND2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin D2 (CCND2) (AA 1-289) protein (GST tag)CCND2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin D2 (CCND2) proteinCCND2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
-
- 抗原
- Cyclin D2 (CCND2)
- 别名
- Cyclin-D2 (CCND2 产品)
- 背景
-
Abbreviation: Cyclin-D2,CCND2
Target Synonym: G1/S-specific cyclin-D2,CCND2
Background: CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition. It is also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- 分子量
-
Calculated MW: 31.68 kDa
Observed MW: 38 kDa
- UniProt
- P30279
- 途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
-
