CSF1R Protein (AA 20-512)
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北京 101111
Quick Overview for CSF1R Protein (AA 20-512) (ABIN7504465)
抗原
See all CSF1R 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 20-512
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原理
- Human M-CSF R/CSF1R/CD115 Protein
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序列
- Ile20-Glu512
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产品特性
- Recombinant Human M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 without tag.It contains Ile20-Glu512.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1 EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human M-CSF R, No Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 8.0ng/ml determined by ELISA (QC Test).,Human M-CSF R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,Loaded Human M-CSF, His Tag on Anti-His-Biosensor can bind Human M-CSF R, No Tag with an affinity constant of 0.46 μM as determined in BLI assay (Gator® Prime).,The purity of Human M-CSF R is greater than 95% as determined by SEC-HPLC.
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Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) (Active) protein (His tag)
CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (hFc Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (Biotin,His-Avi Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) (Active) protein (His-Avi Tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-514) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 20-512) protein (His tag)CSF1R 宿主: 人 宿主: HEK-293 Cells Recombinant >96 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) (AA 99-596) protein (Fc Tag)CSF1R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) protein (Fc Tag)CSF1R 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) protein (His tag)CSF1R 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Colony Stimulating Factor 1 Receptor (CSF1R) (Active) protein (His tag)CSF1R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.
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缓冲液
- Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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有效期
- 12 months
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- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
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别名
- M-CSF R
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背景
- CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
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分子量
- 54.49 kDa. Due to glycosylation, the protein migrates to 70-100 kDa based on Bis-Tris PAGE result.
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UniProt
- P07333
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途径
- RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
抗原
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