Angiopoietin 2 Protein (ANGPT2) (His tag)
Quick Overview for Angiopoietin 2 Protein (ANGPT2) (His tag) (ABIN7488954)
抗原
See all Angiopoietin 2 (ANGPT2) 蛋白蛋白类型
宿主
资源
纯度
质量等级
-
-
标记
- This Angiopoietin 2 protein is labelled with His tag.
-
原理
- Rabbit Angiopoietin-2 / ANGPT2 Protein, His Tag (MALS verified)
-
序列
- Lys 275 - Phe 496
-
产品特性
- Rabbit Angiopoietin-2 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496 (Accession # G1T9B3-1).
-
内毒素水平
- 1.0 EU per μg
-
-
Angiopoietin 2 (ANGPT2) (AA 275-496) protein (His-Avi Tag)
ANGPT2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Angiopoietin 2 (ANGPT2) (AA 275-496) protein (His tag)ANGPT2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Angiopoietin 2 (ANGPT2) (AA 275-496) protein (His-Avi Tag,Biotin)ANGPT2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Angiopoietin 2 (ANGPT2) protein (Fc Tag)ANGPT2 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Angiopoietin 2 (ANGPT2) (AA 275-496) protein (His tag)ANGPT2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Angiopoietin 2 (ANGPT2) (AA 19-496) protein (His tag)ANGPT2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Angiopoietin 2 (ANGPT2) (AA 19-496) (Active) protein (His tag)ANGPT2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Angiopoietin 2 (ANGPT2) (AA 275-496) (Active) protein (His tag,AVI tag,Biotin)ANGPT2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
-
-
说明
-
This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 27.4 kDa. The protein migrates as 30-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 20 mM MOPS, 5 mM CHAPS, 150 mM NaCl, pH 7.5
-
储存条件
- -20 °C
-
储存方法
- -20°C
-
-
- Angiopoietin 2 (ANGPT2)
-
别名
- Angiopoietin-2
-
背景
- Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.
-
分子量
- 27.4 kDa
-
途径
- RTK signaling
抗原
-
