Tspan-8 Protein (His tag)
Quick Overview for Tspan-8 Protein (His tag) (ABIN7488814)
抗原
See all Tspan-8 (TSPAN8) 蛋白蛋白类型
宿主
资源
纯度
质量等级
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标记
- This Tspan-8 protein is labelled with His tag.
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原理
- Mouse TSPAN8 Protein, His Tag (MALS verified)
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序列
- Gly 106 - Asn 203
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产品特性
- Mouse TSPAN8 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Gly 106 - Asn 203 (Accession # Q8R3G9-1).
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内毒素水平
- 1.0 EU per μg
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!探索我们的预定义定制蛋白和定制蛋白服务!Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Mouse价格从 136,947.45 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Mouse价格从 172,528.32 ¥您的项目需要进一步定制吗?联系我们,了解我们的定制蛋白解决方案
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说明
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This protein carries a polyhistidine tag at the N-terminus. (10xHis) The protein has a calculated MW of 12.8 kDa. The protein migrates as 15-19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- -20°C
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- Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))
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别名
- TSPAN8
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背景
- Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form 'tetraspanin webs'. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell-cell and cell-matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.
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分子量
- 12.8 kDa
抗原
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