IL12RB2 Protein (His tag)
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- 抗原 See all IL12RB2 蛋白
- IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL12RB2 protein is labelled with His tag.
- 原理
- Human IL-12 R beta 2 Protein, His Tag (MALS verified)
- 序列
- Lys 24 - Asn 622
- 产品特性
- Human IL-12 R beta 2, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 24 - Asn 622 (Accession # Q99665-1).
- 纯度
- 95 %
- 内毒素水平
- 1.0 EU per μg
- 质量等级
- MALS verified
- Top Product
- Discover our top product IL12RB2 蛋白
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Interleukin 12 Receptor, beta 2 (IL12RB2) protein (Fc Tag)
IL12RB2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Interleukin 12 Receptor, beta 2 (IL12RB2) (AA 105-214) protein (GST tag)IL12RB2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 12 Receptor, beta 2 (IL12RB2) (AA 1-862) protein (GST tag)IL12RB2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 说明
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This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 70.0 kDa. The protein migrates as 66 kDa and 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))
- 别名
- IL-12 R beta 2 (IL12RB2 产品)
- 背景
- The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas, IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy.
- 分子量
- 70.0 kDa
- 途径
- JAK/STAT Signaling
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