Quick Overview for FGF10 蛋白 (ABIN7455677)
抗原
See all FGF10 蛋白蛋白类型
宿主
资源
纯度
-
-
原理
- Recombinant Human Fibroblast Growth Factor 10 is produced by our E.coli expression system and the target gene encoding Gln38-Ser208 is expressed.
-
产品特性
- Extracellular Domain Protein
-
纯化方法
- Affinity purification
-
-
Fibroblast Growth Factor 10 (FGF10) (AA 38-208) protein (Biotin)
FGF10 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fibroblast Growth Factor 10 (FGF10) (AA 38-208) proteinFGF10 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % as determined by Tris-Bis PAGE
Fibroblast Growth Factor 10 (FGF10) (AA 38-137) protein (GST tag)FGF10 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor 10 (FGF10) (AA 37-215) protein (His-IF2DI Tag)FGF10 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fibroblast Growth Factor 10 (FGF10) (AA 1-208) protein (GST tag)FGF10 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, pH 8.0.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
-
有效期
- 12 months
-
-
- FGF10 (Fibroblast Growth Factor 10 (FGF10))
-
别名
- FGF-10
-
背景
- Fibroblast growth factor 10 (FGF-10, KGF-2), is a member of the fibroblast growth factor (FGF) family that includes FGF-3, -7, and -22. KGF-2 is secreted by mesenchymal cells and associates with extracellular FGF-BP. It preferentially binds and activates epithelial cell FGFR2 and interacts more weakly with FGFR1. It plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 is required for normal branching morphogenesis. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
-
分子量
- 19.5 KDa
-
UniProt
- O15520
-
途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Tube Formation, Positive Regulation of Response to DNA Damage Stimulus
抗原
-
