LDLR 蛋白
Quick Overview for LDLR 蛋白 (ABIN7447870)
抗原
See all LDLR 蛋白蛋白类型
宿主
资源
纯度
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原理
- Human LDL R Protein, Tag Free
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序列
- Ala 22 - Arg 788
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产品特性
- Human LDL R, Tag Free is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Arg 788 (Accession # P01130-1).
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内毒素水平
- 1.0 EU per μg
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Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His tag)
LDLR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His-Avi Tag)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Low Density Lipoprotein Receptor (LDLR) (AA 105-205) protein (GST tag)LDLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His-Avi Tag,Biotin)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) (Active) protein (His tag)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) (Active) protein (His tag)LDLR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Low Density Lipoprotein Receptor (LDLR) (AA 455-607) protein (His-IF2DI Tag)LDLR 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Low Density Lipoprotein Receptor (LDLR) (Active) protein (His tag)LDLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Low Density Lipoprotein Receptor (LDLR) (AA 1-860) protein (GST tag)LDLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His tag)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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说明
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This protein carries no "tag". The protein has a calculated MW of 24.6 kDa. The protein migrates as 80-90 kDa and 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- -20°C
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- LDLR (Low Density Lipoprotein Receptor (LDLR))
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别名
- LDL R
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背景
- Synonyms:LDLR,FH,FHC,LDLCQ2,Description:Low-Density Lipoprotein (LDL) Receptor is also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70 % of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol, if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.
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分子量
- 24.6 kDa
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途径
- Hepatitis C, Lipid Metabolism
抗原
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