ITGAV/ITGB6 Protein (AA 31-992) (His-Avi Tag,Biotin)
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- 抗原 See all ITGAV/ITGB6 products
- ITGAV/ITGB6 (Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6))
- 蛋白类型
- Recombinant
- 产品特性
- AA 31-992
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ITGAV/ITGB6 protein is labelled with His-Avi Tag,Biotin.
- 原理
- Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein
- 序列
- Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail
- 特异性
- Uni-Prot: P06756-1 (ITGAV), P18564-1 (ITGB6)
- 产品特性
- Recombinant Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human Latent TGF beta 1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human ITGAV&ITGB6, His Tag with the EC50 of 1.2μg/ml determined by ELISA. See testing image for detail.
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Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-988) protein (His tag)
ITGAV/ITGB6 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-993) protein (His tag)ITGAV/ITGB6 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB6 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) (Active) protein (His tag,AVI tag,Biotin)ITGAV/ITGB6 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- ITGAV/ITGB6 (Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6))
- 别名
- Integrin alpha V beta 6 (ITGAV & ITGB6) Heterodimer (ITGAV/ITGB6 产品)
- 背景
- ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
- 分子量
- 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on Tris-Bis PAGE result.
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