IL21 Receptor Protein (AA 20-236) (Fc Tag)
Quick Overview for IL21 Receptor Protein (AA 20-236) (Fc Tag) (ABIN7275021)
抗原
See all IL21 Receptor (IL21R) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 20-236
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标记
- This IL21 Receptor protein is labelled with Fc Tag.
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原理
- Human IL-21R Protein
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序列
- Cys20-Pro236
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产品特性
- Recombinant Human IL-21R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Cys20-Pro236.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1EU per μg by the LAL method.
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Biological Activity Comment
- Immobilized Human IL-21, No Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human IL-21R, hFc Tag with the EC50 of 63.6ng/ml determined by ELISA. See testing image for detail.
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Interleukin 21 Receptor (IL21R) (AA 20-232) protein (His tag)
IL21R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 21 Receptor (IL21R) (AA 41-254) protein (His tag)IL21R 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 21 Receptor (IL21R) (AA 20-232) protein (mFc Tag)IL21R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 21 Receptor (IL21R) (AA 20-232) protein (Fc Tag)IL21R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 21 Receptor (IL21R) protein (His tag)IL21R 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Interleukin 21 Receptor (IL21R) (AA 1-538) protein (GST tag)IL21R 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 21 Receptor (IL21R) (Active) protein (His tag)IL21R 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 21 Receptor (IL21R) (AA 20-236) (Active) protein (His tag)IL21R 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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有效期
- 12 months
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- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
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别名
- IL-21R
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背景
- IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
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分子量
- 51.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
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NCBI登录号
- NP_068570
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途径
- JAK/STAT Signaling
抗原
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