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Annexin A2 Protein (ANXA2) (AA 2-339) (His tag)

ANXA2 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by Tris-Bis PAGE
产品编号 ABIN7273846
发货至: 中国
  • 抗原 See all Annexin A2 (ANXA2) 蛋白
    Annexin A2 (ANXA2)
    蛋白类型
    Recombinant
    产品特性
    AA 2-339
    宿主
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 11
    • 7
    • 6
    • 3
    大肠杆菌(E. Coli)
    标记
    This Annexin A2 protein is labelled with His tag.
    原理
    Mouse ANXA2 Protein
    序列
    Ser2-Asp339
    产品特性
    Recombinant Mouse ANXA2 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Ser2-Asp339.
    纯度
    > 95 % as determined by Tris-Bis PAGE
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1EU per μg by the LAL method.
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  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in 20 mM MES, 150 mM NaCl, 200 mM L-arginine, 5 mM DTT ( pH 5.5).
    缓冲液
    Lyophilized from 0.22μm filtered solution in 20 mM MES, 150 mM NaCl, 200 mM L-arginine, 5 mM DTT ( pH 5.5). Normally 8 % trehalose is added as protectant before lyophilization.
    储存液
    Dithiothreitol (DTT)
    注意事项
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Annexin A2 (ANXA2)
    别名
    ANXA2 (ANXA2 产品)
    背景
    ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
    分子量
    39.6 kDa same as Tris-Bis PAGE result.
    UniProt
    P07356
    途径
    S100 Proteins
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