Annexin A2 Protein (ANXA2) (AA 2-339) (His tag)
Quick Overview for Annexin A2 Protein (ANXA2) (AA 2-339) (His tag) (ABIN7273844)
抗原
See all Annexin A2 (ANXA2) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 2-339
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标记
- This Annexin A2 protein is labelled with His tag.
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原理
- Human ANXA2 Protein
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序列
- Ser2-Asp339
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产品特性
- Recombinant Human ANXA2 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Ser2-Asp339.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1EU per μg by the LAL method.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
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缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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有效期
- 12 months
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- Annexin A2 (ANXA2)
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别名
- ANXA2
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背景
- ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
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分子量
- 39.6 kDa same as Tris-Bis PAGE result.
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UniProt
- P07355
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途径
- S100 Proteins
抗原
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