Abeta 1-42 Protein (AA 672-713) (His-GST)
This Recombinant Abeta 1-42 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7317786
发货至:
中国
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Quick Overview for Abeta 1-42 Protein (AA 672-713) (His-GST) (ABIN7317786)
抗原
Abeta 1-42
(Amyloid beta 1-42 (Abeta 1-42))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 80 % as determined by reducing SDS-PAGE.
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产品特性
- AA 672-713
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标记
- This Abeta 1-42 protein is labelled with His-GST.
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原理
- Recombinant Human Beta-amyloid 42/Beta-APP42 Protein (His & GST Tag)
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序列
- Asp672-Ala713
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产品特性
- A DNA sequence encoding the amino acids (Asp672-Ala713) of human Amyloid beta A4 protein (APP770) (P05067-1), corresponding to the Beta-amyloid protein 42, was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, 10 % glycerol, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Abeta 1-42 (Amyloid beta 1-42 (Abeta 1-42))
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别名
- Beta-amyloid 42
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背景
- AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN-II,PN2,Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can be processed by two different proteolytic pathways. In one pathway, APP is cleaved by β- and γ-secretase to produce the amyloid-β-protein (Aβ, Abeta, beta-amyloid) which is the principal component of the amyloid plaques, the major pathological hallmark of Alzheimer's disease (AD), while in the other pathway, α-secretase is involved in the cleavage of APP whose product exerts antiamyloidogenic effect and prevention of the Aβ peptide formation. The aberrant accumulation of aggregated beta-amyloid peptides (Abeta) as plaques is a hallmark of AD neuropathology and reduction of Abeta has become a leading direction of emerging experimental therapies for the disease. Abeta may be part of a mechanism controlling synaptic activity, acting as a positive regulator presynaptically and a negative regulator postsynaptically. The pathological accumulation of oligomeric Abeta assemblies depresses excitatory transmission at the synaptic level, but also triggers aberrant patterns of neuronal circuit activity and epileptiform discharges at the network level. There is evidence that beta-amyloid can impair blood vessel function. Vascular beta-amyloid deposition, also known as cerebral amyloid angiopathy, is associated with vascular dysfunction in animal and human studies.
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分子量
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Calculated MW: 32.4 kDa
Observed MW: 34 kDa
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基因ID
- 351
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UniProt
- P05067
抗原
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