Quick Overview for DLL1 Protein (Fc Tag) (ABIN7319919)
抗原
See all DLL1 蛋白蛋白类型
宿主
资源
纯度
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标记
- This DLL1 protein is labelled with Fc Tag.
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原理
- Recombinant Human Delta-like Protein 1/DLL1 (C-Fc)
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序列
- Gln18-Gly540
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产品特性
- Recombinant Human Delta-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Gln18-Gly540 is expressed with a Fc tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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delta-Like 1 (DLL1) (AA 18-540) protein (His tag)
DLL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
delta-Like 1 (DLL1) (Active) protein (His tag)DLL1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
delta-Like 1 (DLL1) (AA 18-545) (Active) protein (Fc Tag)DLL1 宿主: 人 宿主: CHO Cells Recombinant >90 % (SDS-PAGE) SDS Active
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说明
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90-100 kDa
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM Hepes, 150 mM NaCl, 1 mM EDTA, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- DLL1 (delta-Like 1 (DLL1))
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别名
- DLL1
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背景
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Background: Delta-like protein 1 (DLL1) is a type I transmembrane protein that belongs to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Mature human DLL1 consists of a 528 amino acid (aa) extracellular domain (ECD) with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane segment, and a 155 aa cytoplasmic domain. Within the ECD, human DLL1 shares 91 % aa sequence identity with mouse and rat DLL1. The residual membranebound portion of DLL1 can be cleave by presenilin-dependent γ-secretase, enabling the cytoplasmic domain to migrate to the nucleus. DLL1 localizes to adherens junctions on neuronal processes through its association with the scaffolding protein MAGI1. DLL1 is widely expressed, and it plays an important role in embryonic somite formation, cochlear hair cell differentiation, plus B and T lymphocyte differentiation. The upregulation of DLL1 in arterial endothelial cells following injury or angiogenic stimulation is central to postnatal arteriogenesis. DLL1 is also overexpressed in cervical carcinoma and glioma and contributes to tumor progression.
Synonym: Delta-like protein 1, Drosophila Delta homolog 1, Delta1, H-Delta-1, DLL1
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分子量
- 83.3 kDa
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UniProt
- O00548
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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