Quick Overview for ErbB2/Her2 Protein (Biotin) (ABIN7319859)
抗原
See all ErbB2/Her2 蛋白蛋白类型
宿主
资源
纯度
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标记
- This ErbB2/Her2 protein is labelled with Biotin.
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原理
- Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-2/HER2 (C-Fc-Avi) Biotinylated
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序列
- Thr23-Thr652
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产品特性
- Biotinylated Recombinant Human Receptor tyrosine-protein kinase ErbB-2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc, Avi tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His-Avi Tag)
ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His-Avi Tag,Biotin)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His tag)ErbB2/Her2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (Fc Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) protein (His-Avi Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 1-1255) protein (GST tag)ErbB2/Her2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) protein (His tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 489-630) protein (His-Avi Tag,Biotin)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) protein (Fc Tag)ErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-652) (Active) proteinErbB2/Her2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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说明
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120-140 kDa
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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别名
- HER2
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背景
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Background: Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Synonym: Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Tyrosine kinase-type cell surface receptor HER2, ERBB2, MLN19, NGL, TKR1
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分子量
- 98.3 kDa
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UniProt
- P04626
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
抗原
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