UNG Protein (GST tag)
Quick Overview for UNG Protein (GST tag) (ABIN7317329)
抗原
See all UNG 蛋白蛋白类型
宿主
资源
纯度
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标记
- This UNG protein is labelled with GST tag.
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原理
- Recombinant Human Uracil-DNA glycosylase/UNG Protein (GST Tag)
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序列
- Phe 85-Leu 304
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产品特性
- A DNA sequence encoding the human UNG isoform 1 (P13051-2) (Phe 85-Leu 304) was fused with the GST tag at the N-terminus.
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Uracil-DNA Glycosylase (UNG) (AA 1-313) protein (His tag)
custom-made UNG 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Uracil-DNA Glycosylase (UNG) (AA 1-229) protein (His tag)UNG 宿主: E. coli 宿主: 大肠杆菌（E. Coli） Recombinant > 90% by SDS-PAGE SDS
Uracil-DNA Glycosylase (UNG) (AA 1-304) protein (GST tag)UNG 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Uracil-DNA Glycosylase (UNG) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)UNG 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 40 mM Tris, 0.15M NaCl, 2 mM GSH, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- UNG (Uracil-DNA Glycosylase (UNG))
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别名
- Uracil-DNA glycosylase/UNG
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物质类
- Viral Protein
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背景
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Background: Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
Synonym: DGU,HIGM4,HIGM5,UDG,UNG1,UNG15,UNG2
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分子量
- 52 kDa
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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