USP7 Protein (AA 208-560) (His-GST)
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Quick Overview for USP7 Protein (AA 208-560) (His-GST) (ABIN7198567)
抗原
See all USP7 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 208-560
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标记
- This USP7 protein is labelled with His-GST.
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原理
- Recombinant Human USP7/HAUSP Protein (aa 208-560, His & GST Tag)
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序列
- Lys 208-Glu 560
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产品特性
- A DNA sequence encoding the amino acid sequence (Lys 208-Glu 560) of human USP7 (NP_003461.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 13-110) protein (GST tag)
USP7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) (AA 214-521) protein (His-IF2DI Tag)USP7 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) protein (Myc-DYKDDDDK Tag)USP7 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM EDTA, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存液
- PMSF
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
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别名
- USP7/HAUSP
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背景
- HAUSP,TEF1,Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein which belongs to thepeptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 stimulates lytic infection and the reactivation of quiescent viral genomes. ICP0 interacts very strongly with USP7. USP7-mediated stabilization of ICP0 is dominant over ICP0-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP0-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP0 are expressed.
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分子量
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Calculated MW: 68.8 kDa
Observed MW: 60 kDa
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基因ID
- 7874
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NCBI登录号
- NP_003461
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UniProt
- Q93009
抗原
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