Thrombospondin 1 Protein (THBS1) (His tag)
Quick Overview for Thrombospondin 1 Protein (THBS1) (His tag) (ABIN7319437)
抗原
See all Thrombospondin 1 (THBS1) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Thrombospondin 1 protein is labelled with His tag.
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原理
- Recombinant Human Thrombospondin-1/THBS1 Protein (His Tag)(Active)
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序列
- Asn19-Pro1170
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产品特性
- Recombinant Human Thrombospondin-1 is produced by our Mammalian expression system and the target gene encoding Asn19-Pro1170 is expressed with a 10His tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- Immobilized Rhesus macaque CD47-Fc(Cat: PKSQ050076) at 10μg/ml(100 μl/well) can bind Human THBS1-His.
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Thrombospondin 1 (THBS1) (AA 19-350) protein (His tag)
THBS1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombospondin 1 (THBS1) (AA 19-344) protein (His tag)THBS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombospondin 1 (THBS1) (AA 19-265) protein (His tag)THBS1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Thrombospondin 1 (THBS1)
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别名
- Thrombospondin-1/THBS1
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背景
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Background: Thrombospondin-1 (TSP-1) is a 150-180 kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have been associated with binding to particular ECM or cellular molecules. TSP-1 counteracts the angiogenic, hypotensive, and antithrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGF R2 signaling on vascular endothelial cells(EC), and destabilizes adhesive contacts between EC. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP).
Synonym: Thrombospondin-1, THBS1, TSP, TSP1
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分子量
- 129.2 kDa
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UniProt
- P07996
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途径
- Autophagy
抗原
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