SOCS3 Protein (His-TRX)
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北京 101111
Quick Overview for SOCS3 Protein (His-TRX) (ABIN7317579)
抗原
See all SOCS3 蛋白蛋白类型
宿主
资源
纯度
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标记
- This SOCS3 protein is labelled with His-TRX.
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原理
- Recombinant Human SOCS3/CIS3 Protein (His & Trx Tag)
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序列
- Met 1-Leu 225
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产品特性
- A DNA sequence encoding the human SOCS3 (O14543) (Met 1-Leu 225) was fused with a Trx and a polyhistide tag at the N-terminus.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (GST tag)
SOCS3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) protein (His-IF2DI Tag)SOCS3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) (Active) protein (His tag)SOCS3 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） > 97 % AcA, CC Active
Suppressor of Cytokine Signaling 3 (SOCS3) protein (Myc-DYKDDDDK Tag)SOCS3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
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别名
- SOCS3/CIS3
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背景
- ATOD4,CIS3,Cish3,SOCS-3,SSI-3,SSI3,Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains oneSH2 domain and oneSOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.
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分子量
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Calculated MW: 41.9 kDa
Observed MW: 46 kDa
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基因ID
- 9021
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UniProt
- O14543
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
抗原
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