SPG21 Protein (His-GST)
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北京 101111
Quick Overview for SPG21 Protein (His-GST) (ABIN7320147)
抗原
See all SPG21 蛋白蛋白类型
宿主
资源
纯度
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标记
- This SPG21 protein is labelled with His-GST.
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原理
- Recombinant Mouse SPG21 Protein (His & GST Tag)
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序列
- Met 1-Pro 308
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产品特性
- A DNA sequence encoding the mouse SPG21 isoform 1 (Q9CQC8-1) (Met 1-Pro 308) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Mouse价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Mouse价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Spastic Paraplegia 21 (SPG21) (AA 1-308) protein (His tag)
custom-made SPG21 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Spastic Paraplegia 21 (SPG21) (AA 1-308) protein (His tag)custom-made SPG21 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Spastic Paraplegia 21 (SPG21) (AA 1-308) protein (GST tag)SPG21 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Spastic Paraplegia 21 (SPG21) (AA 1-308) protein (His tag)SPG21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS
Spastic Paraplegia 21 (SPG21) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)SPG21 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 3 mM DTT, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- SPG21 (Spastic Paraplegia 21 (SPG21))
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别名
- SPG21
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背景
- ACP33,BM-019,C78576,D9Wsu18e,GL010,MAST,Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of the AB hydrolase superfamily. Human SPG21 is a 308 amino acid residue protein widely expressed in all tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. SPG21 binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation via the noncatalytic alpha/beta hydrolase fold domain. SPG21 thus is proposed to play a role as a negative regulatory factor in CD4-dependent T-cell activation of CD4. Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21, also known as Mast syndrome, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. SPG21 is also associated with dementia and other central nervous system abnormalities.
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分子量
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Calculated MW: 62.8 kDa
Observed MW: 52 kDa
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UniProt
- Q9CQC8
抗原
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