S100A12 Protein (AA 1-92)
This Recombinant S100A12 protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN7319473
发货至:
中国
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Quick Overview for S100A12 Protein (AA 1-92) (ABIN7319473)
抗原
See all S100A12 蛋白
S100A12
(S100 Calcium Binding Protein A12 (S100A12))
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % as determined by reducing SDS-PAGE.
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产品特性
- AA 1-92
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原理
- Recombinant Human S100A12/CAGC Protein
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序列
- Met1-Glu92
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产品特性
- Recombinant Human S100A12 is produced by our E.coli expression system and the target gene encoding Met1-Glu92 is expressed.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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S100 Calcium Binding Protein A12 (S100A12) (AA 1-92) protein (GST tag)
S100A12 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
S100 Calcium Binding Protein A12 (S100A12) (AA 2-92) protein (His-IF2DI Tag)S100A12 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- S100A12 (S100 Calcium Binding Protein A12 (S100A12))
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别名
- S100A12/CAGC
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背景
- CGRP,Calcitermin,Calcium-binding protein in amniotic fluid 1,Calgranulin-C,EN-RAGE,Extracellular newly identified RAGE-binding protein,MRP-6,Migration inhibitory factor-related protein 6,Protein S100-A12,S100 calcium-binding protein A12,S100A12,There are at least 21 different S100 proteins and the protein is 100 % soluble in ammonium sulfate at neutral pH . S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. S100A12 is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites.
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分子量
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Calculated MW: 10.6 kDa
Observed MW: 11 kDa
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基因ID
- 6283
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UniProt
- P80511
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途径
- Toll-Like Receptors Cascades, S100 Proteins
抗原
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