Ret Proto-Oncogene Protein (RET) (His tag)
Quick Overview for Ret Proto-Oncogene Protein (RET) (His tag) (ABIN7317437)
抗原
See all Ret Proto-Oncogene (RET) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Ret Proto-Oncogene protein is labelled with His tag.
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原理
- Recombinant Human RET Kinase Protein (His Tag)
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序列
- Met 1-Arg 635
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产品特性
- A DNA sequence encoding the extracellular domain of human RET (P07949-1) (Met 1-Arg 635) was fused with a polyhistidine tag at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Ret Proto-Oncogene (RET) (AA 25-458) protein (GST tag)
RET 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Ret Proto-Oncogene (RET) (AA 658-1114) (Active) protein (GST tag,His tag)RET 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Ret Proto-Oncogene (RET) (AA 29-635) protein (His tag)RET 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Ret Proto-Oncogene (RET) protein (DYKDDDDK Tag)RET 宿主: 人 宿主: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Ret Proto-Oncogene (RET)
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别名
- RET Kinase
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背景
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Background: RET proto-oncogene; also known as RET; is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily; tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation; neuronal navigation; cell migration; and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life; promotes the formation of Peyer's patch-like structures; modulates cell adhesion via its cleavage; involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand; triggering apoptosis. RET acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary); promotes survival and down regulates growth hormone (GH) production; but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size; triggers the differentiation of rapidly adapting (RA) mechanoreceptors; mediated several diseases such as neuroendocrine cancers. Defects in RET may cause colorectal cancer; hirschsprung disease type 1; medullary thyroid carcinoma; multiple neoplasia type 2B; susceptibility to pheochromocytoma; multiple neoplasia type 2A; thyroid papillary carcinoma and congenital central hypoventilation syndrome.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: CDHF12;CDHR16;HSCR1;MEN2A;MEN2B;MTC1;PTC;RET-ELE1;RET51
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分子量
- 69.1 kDa
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途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
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