Ret Proto-Oncogene Protein (RET) (AA 658-1114) (His-GST)
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Quick Overview for Ret Proto-Oncogene Protein (RET) (AA 658-1114) (His-GST) (ABIN7317056)
抗原
See all Ret Proto-Oncogene (RET) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 658-1114
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标记
- This Ret Proto-Oncogene protein is labelled with His-GST.
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原理
- Recombinant Human RET Kinase Protein (aa 658-1114, His & GST Tag)
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序列
- His 658-Ser 1114
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产品特性
- A DNA sequence encoding the cytoplasmic domain of human RET (P07949-1) (His 658-Ser 1114) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 17 nmol/min/mg using synthetic TRK-C-derived Peptide (R11-VYSTDYYRLFNPS) as substrate.
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Ret Proto-Oncogene (RET) (AA 25-458) protein (GST tag)
RET 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Ret Proto-Oncogene (RET) (AA 29-635) protein (His tag)RET 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- Ret Proto-Oncogene (RET)
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别名
- RET Kinase
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背景
- CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51,RET proto-oncogene, also known as RET, is a cell-surface molecule that transduce signals for cell growth and differentiation. It contains 1 cadherin domain and 1 protein kinase domain. RET proto-oncogene belongs to the protein kinase superfamily, tyr protein kinase family. RET proto-oncogene is involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. It phosphorylates PTK2/FAK1 and regulates both cell death/survival balance and positional information. RET is required for the molecular mechanisms orchestration during intestine organogenesis, involved in the development of enteric nervous system and renal organogenesis during embryonic life, promotes the formation of Peyer's patch-like structures, modulates cell adhesion via its cleavage, involved in the development of the neural crest. RET proto-oncogene is active in the absence of ligand, triggering apoptosis. RET acts as a dependence receptor, in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. It also regulates nociceptor survival and size, triggers the differentiation of rapidly adapting (RA) mechanoreceptors, mediated several diseases such as neuroendocrine cancers.
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分子量
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Calculated MW: 76.7 kDa
Observed MW: 70 kDa
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基因ID
- 5979
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UniProt
- P07949
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途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
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