Renin Protein (REN) (AA 22-402) (His tag)
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Quick Overview for Renin Protein (REN) (AA 22-402) (His tag) (ABIN7320778)
抗原
See all Renin (REN) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 22-402
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标记
- This Renin protein is labelled with His tag.
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原理
- Recombinant Mouse REN1/Renin-1 Protein (His Tag)
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序列
- Leu22-Arg402
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产品特性
- Recombinant Mouse Renin is produced by our Mammalian expression system and the target gene encoding Leu22-Arg402 is expressed with a 10His tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Renin (REN) (AA 24-406) protein (His tag)
REN 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Renin (REN) (Active) protein (His tag)REN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. ELISA Active
Renin (REN) (AA 24-406) protein (GST tag)REN 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Renin (REN)
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别名
- REN1/Renin-1
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背景
- Angiotensin-forming enzyme,Angiotensinogenase,Kidney renin,Ren,Ren-1,Ren-A,Ren1,Ren1c,Ren1d,Renin-1,Rn-1,Rnr,Mouse Renin, also known as Renin-1,is a member of the peptidase A1 amily. Renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. It cleaves angiotensinogen to generate angiotensin I, which can be further converted by angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II is the active molecule of the reninangiotensin system that acts by binding to angiotensin receptors type 1 and 2 (AT1 and AT2),and has direct pathophysiological effects on the heart and peripheral vasculature. After secretion, inactive prorenin can be proteolytically activated by trypsin, cathepsin B, or other proteinases.
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分子量
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Calculated MW: 43.5 kDa
Observed MW: 41-60 kDa
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基因ID
- 19701
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UniProt
- P06281
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途径
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour
抗原
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