PDK4 Protein (AA 1-412) (His-GST)
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北京 101111
Quick Overview for PDK4 Protein (AA 1-412) (His-GST) (ABIN7320000)
抗原
See all PDK4 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 1-412
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标记
- This PDK4 protein is labelled with His-GST.
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原理
- Recombinant Mouse PDK4 Protein (His & GST Tag)
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序列
- Met1-Val412
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产品特性
- A DNA sequence encoding the mouse PDK4 (O70571) (Met1-Val412) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Kinase activity untested
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Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 1-411) protein (GST tag)
PDK4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) (AA 138-368) protein (His-IF2DI Tag)PDK4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) protein (Myc-DYKDDDDK Tag)PDK4 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4) proteinPDK4 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))
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别名
- PDK4
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背景
- AV005916,Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC).PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.
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分子量
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Calculated MW: 74.4 kDa
Observed MW: 65 kDa
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UniProt
- O70571
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途径
- PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
抗原
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