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PGC Protein (His tag)

This Recombinant PGC protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7317422
发货至: 中国

Quick Overview for PGC Protein (His tag) (ABIN7317422)

抗原

See all PGC 蛋白
PGC (Pepsinogen C (PGC))

蛋白类型

Recombinant

宿主

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资源

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大肠杆菌(E. Coli)

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 标记

    This PGC protein is labelled with His tag.

    原理

    Recombinant Human Pepsinogen C/PGC Protein (E.coli, His Tag)

    序列

    Ile153-Ile239

    产品特性

    A DNA sequence encoding the mature form of human PGC (P20142-1) (Ile153-Ile239) was expressed with a polyhistide tag at the N-terminus.
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from sterile 50 mM Tris, 0.4M sucrose, 1 mM EDTA, 50 mM NaCl, pH 8.0

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    PGC (Pepsinogen C (PGC))

    别名

    Pepsinogen C/PGC

    背景

    Background: Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

    Synonym: PEPC,PGII

    分子量

    10.9 kDa
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