MUC1 蛋白
Quick Overview for MUC1 蛋白 (ABIN7317411)
抗原
See all MUC1 蛋白蛋白类型
宿主
资源
纯度
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原理
- Recombinant Human Mucin-1/MUC-1 Protein
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序列
- Met 1-Gly 167
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产品特性
- A DNA sequence encoding the human MUC1 isoform 2 (NP_001018016.1) extracellular domain (Met 1-Gly 167) was expressed with six amino acids (LEVLFQ) at the C-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Mucin 1 (MUC1) (AA 24-158) protein (Fc Tag)
MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Mucin 1 (MUC1) (AA 315-420) protein (GST tag)MUC1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mucin 1 (MUC1) (AA 24-380) (Active) protein (Fc Tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Mucin 1 (MUC1) (AA 1095-1140) protein (His tag)MUC1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Mucin 1 (MUC1) (AA 1036-1156) protein (Fc Tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Mucin 1 (MUC1) (AA 1036-1156) protein (His tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Mucin 1 (MUC1) (AA 890-1158) protein (His tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Mucin 1 (MUC1) (AA 1036-1155) protein (His tag)MUC1 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- MUC1 (Mucin 1 (MUC1))
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别名
- Mucin-1/MUC-1
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背景
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Background: Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD227; MUC1;ADMCKD;ADMCKD1;CA15-3;MAM6;MCD;MCKD;MCKD1;MUC-1;MUC-1/SEC;MUC-1/X;MUC1/ZD;Mucin 1;PEM
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分子量
- 15.4 kDa
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NCBI登录号
- NP_001018016
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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